Rodent Control & Exterminators in South Carolina (Rats & Mice)

Rodent Control & Exterminators in South Carolina (Rats & Mice)

60 SC-licensed providers · 4.9★ average rating · sorted by rating and reviews · updated July 2026.

Rats and mice are a year-round problem in South Carolina, and they get worse every fall as cooling weather pushes them indoors. Compare SC-licensed rodent exterminators below — ranked by rating, reviews and verified Clemson DPR license — for trapping, removal and the exclusion work that actually keeps them out.

Top-Rated Rodent Control Companies in SC

Rocket Pest Control

Rocket Pest Control

★ 4.8 (4844 reviews)

Greenville, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (864) 618-2851
Rocket Pest Control

Rocket Pest Control

★ 4.8 (4844 reviews)

Greenville, Greenville County

  • household & structural pest control
  • public health pest control
  • structural fumigation
SC Licensed (864) 618-2851
Rocket Pest Control

Rocket Pest Control

★ 4.8 (4844 reviews)

Greenville, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
SC Licensed (864) 618-2851
Rocket Pest Control

Rocket Pest Control

★ 4.8 (4844 reviews)

Greenville, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (864) 618-2851
Harris Pest Control, Inc.

Harris Pest Control, Inc.

★ 4.9 (1864 reviews)

Effingham, Florence County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (843) 665-4325
Walker Pest Management

Walker Pest Management

★ 4.9 (1556 reviews)

Greenville, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (864) 603-1404
RIDD Pest Control

RIDD Pest Control

★ 4.6 (2274 reviews)

North Charleston, Charleston County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (833) 378-0537
American Termapest Inc

American Termapest Inc

★ 5.0 (1157 reviews)

Greenwood, Greenwood County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (864) 571-2431
Orkin

Orkin

★ 4.6 (2054 reviews)

West Columbia, Lexington County

  • aquatic pest control
  • household & structural pest control
  • lawn, turf & ornamental pest treatment
SC Licensed (803) 638-7422
HomeTeam Pest Defense

HomeTeam Pest Defense

★ 4.8 (1383 reviews)

North Charleston, Charleston County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (843) 207-3372
Walker Pest Management

Walker Pest Management

★ 4.9 (1558 reviews)

Greenville, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed +1 864-603-1404
Palmetto Exterminators

Palmetto Exterminators

★ 4.8 (1604 reviews)

Charleston, Charleston County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (800) 585-8019
Palmetto Exterminators

Palmetto Exterminators

★ 4.8 (1604 reviews)

Charleston, Charleston County

  • aquatic pest control
  • household & structural pest control
  • lawn, turf & ornamental pest treatment
SC Licensed (800) 585-8019
Gregory Pest Solutions

Gregory Pest Solutions

★ 4.7 (1111 reviews)

Greenville, Greenville County

  • aquatic pest control
  • household & structural pest control
  • lawn, turf & ornamental pest treatment
SC Licensed (864) 800-1876
Orkin

Orkin

★ 4.8 (939 reviews)

Hardeeville, Jasper County

  • household & structural pest control
  • public health pest control
SC Licensed (843) 505-9080
Palmetto Exterminators

Palmetto Exterminators

★ 4.9 (1143 reviews)

Greer, Charleston County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (888) 293-3377
Croach Pest Control

Croach Pest Control

★ 4.9 (1127 reviews)

Greenville, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (864) 900-3943
Reif Environmental

Reif Environmental

★ 5.0 (577 reviews)

Charleston, Charleston County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (843) 410-3955
Action Pest Services

Action Pest Services

★ 4.9 (526 reviews)

Simpsonville, Greenville County

  • aquatic pest control
  • household & structural pest control
  • lawn, turf & ornamental pest treatment
SC Licensed (864) 399-9262
Go-Forth Pest Control

Go-Forth Pest Control

★ 4.9 (677 reviews)

Fort Mill, Chester County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (839) 400-2165
Patriot Pest Management

Patriot Pest Management

★ 4.9 (448 reviews)

Taylors, Greenville County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • structural fumigation
SC Licensed (864) 210-3569
Palmetto Exterminators

Palmetto Exterminators

★ 4.8 (636 reviews)

Summerville, Charleston County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • public health pest control
SC Licensed (843) 873-7997
Mountaineer Pest Services

Mountaineer Pest Services

★ 4.4 (706 reviews)

North Augusta, Edgefield County

  • household & structural pest control
  • lawn, turf & ornamental pest treatment
  • structural fumigation
SC Licensed (803) 278-1131

Find Rodent Control Near You

Enter your ZIP code or town — or use your location — to see the closest SC-licensed rodent control companies, sorted by distance.

Rats and mice are one of the most common reasons South Carolinians call an exterminator, and the problem is largely seasonal: as nights cool in fall and winter, rodents move from fields and woodlots into warm attics, crawl spaces and wall voids. The state’s mild climate, abundant crawl-space foundations and older housing stock give them plenty of ways in. Along the coast and Lowcountry, roof rats are common and travel through attics, soffits and overhanging trees; in urban Midlands and Upstate neighborhoods, Norway rats and house mice are the usual culprits. Left alone, rodents breed fast, gnaw wiring and insulation, and contaminate food and surfaces — which is why early professional control pays off.

Rat Control & Removal

Rats are cautious and territorial, so effective rat control is rarely a matter of setting a couple of snap traps. A licensed technician starts with an inspection to identify the species, the runways they use, and — most importantly — how they’re getting in. Treatment usually combines mechanical trapping and tamper-resistant bait stations with exclusion: sealing foundation vents, gaps around pipes and utility lines, damaged roofline and soffit areas, and crawl-space access points. In coastal SC homes, roof rats often require attention well above ground level, including tree limbs that act as highways onto the roof. Expect follow-up visits — knocking out an established rat population typically takes several weeks.

Mouse Exterminator Services

House mice are smaller, breed even faster than rats, and can slip through a gap the width of a pencil. They nest indoors year-round and are often first noticed in kitchens, pantries and garages. Professional mouse control pairs interior trapping with sealing the small interior and exterior gaps mice exploit — around dishwashers and plumbing, behind cabinets, and at exterior wall penetrations. Because mice range only a short distance from their nest, technicians place traps tightly along walls and active runways rather than scattering them. As with rats, sealing entry points is what turns a one-time cleanout into a lasting fix.

Rodent Control Cost in SC

A basic rat or mouse job in South Carolina generally runs $200–$450 for an initial visit that includes inspection, trapping and bait placement. Where costs climb is exclusion — the labor of sealing every viable entry point on a home. On larger, older or crawl-space houses, a full exclusion project can run $600–$1,200 or more. Many homeowners then move onto a recurring plan (roughly $40–$70 per quarterly visit) that folds rodent monitoring into general pest service. When you compare quotes, check whether exclusion is included or billed separately — it’s the single biggest driver of both price and long-term results.

Signs of a Rodent Infestation

How to Get Rid of Rodents — and When to Call a Pro

For a single mouse spotted early, DIY snap traps placed tightly against walls, combined with sealing obvious gaps and removing food sources, can be enough. But DIY hits its limits fast: rats are trap-shy, store-bought baits used carelessly can poison pets or non-target wildlife, and trapping without sealing entry points just invites the next wave. Call a licensed SC exterminator when you see droppings in more than one room, hear activity in walls or the attic, find gnawing damage, or keep catching rodents week after week. A pro can identify the species, find the access points you can’t, and combine removal with the exclusion work that actually ends the problem.

Find a Rodent Exterminator Near You

Rodent Control in SC — FAQ

How much does rodent control cost in South Carolina?

A basic rat or mouse job in SC usually runs $200–$450 for an initial visit with trapping and bait, while full exclusion work — sealing entry points, vents and crawl-space gaps — can push a project to $600–$1,200 or more on larger or older homes. Most companies fold ongoing monitoring into a recurring plan at roughly $40–$70 per quarterly visit.

What's the difference between rats and mice in my home?

Mice are small (2–4 inches plus tail), curious and tend to nest indoors in walls, attics and pantries; you'll see scattered rice-grain droppings. Rats are much larger, more cautious, and along the SC coast are often roof rats that travel attics, soffits and trees. Rats leave bigger droppings and cause heavier gnawing damage. The control approach overlaps, but rats usually demand more trapping and tighter exclusion.

How long does it take to get rid of rodents?

A mouse problem caught early can be knocked down in a week or two. An established rat population, especially with attic or crawl-space access, typically takes several weeks of trapping plus sealing the entry points so they can't return. Reputable SC companies schedule follow-up visits rather than promising a one-and-done fix.

Do rodent exterminators seal up the house, or just set traps?

The good ones do both. Trapping and baiting remove the animals already inside; exclusion — sealing gaps around pipes, vents, rooflines and crawl-space foundation vents — is what stops the next wave. Ask whether a quote includes exclusion, because trapping alone rarely solves a recurring rodent issue in SC's older and crawl-space homes.

Are these rodent control companies licensed?

Yes. Every company listed holds a South Carolina pesticide license from Clemson DPR, and we show each provider's license categories and number of certified applicators on its profile so you can verify credentials before you call.